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  • Variant of Uncertain Significance (VUS)
    When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
  • What to do if your genetic test finds a variant of uncertain . . .
    But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
  • Understanding genetic variants of uncertain significance - PMC
    If a VUS is found to be inherited from an unaffected parent, the variant is less likely to be pathogenic If a child has two VUSs in a gene that typically cause disease in an autosomal recessive manner, testing parents will clarify if the VUSs are in the same or different copies of the gene
  • What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . .
    What to do if your genetic test results include a VUS If you have one or more VUSs in your genetic test results, the most important next step is to talk with a neuromuscular specialist or genetic counselor They can look at the whole picture and decide what, if anything, to do next
  • VUS Variant of Uncertain Significance for cancer patients - MC1185-82
    Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
  • Genetic Test Result: VUS - Variant of Uncertain Significance
    A VUS result could get changed to either benign or pathogenic with new information For some variants, a different test can measure if the gene is working or not
  • VUS – The Most Maligned Result in Genetic Testing
    The classification of genetic variants, based on the ACMG guidelines, is usually a five-tiered scheme which describes the quantity and quality of evidence needed to classify the variant as pathogenic, likely pathogenic, a variant of uncertain significance (VUS), likely benign, or benign
  • Rates and Classification of Variants of Uncertain Significance in . . .
    In general, VUS rates were highest in individuals who were not of European White descent (eg, Asian, Black, Hispanic, Native American, Pacific Islander, and Sephardic Jewish) and in genes associated with disorders of incomplete penetrance
  • Definition of variant of uncertain significance - NCI Dictionary of . . .
    A change in a gene’s DNA sequence that has an unknown effect on a person’s health There is usually not enough information about a variant of uncertain significance to know whether it increases a person’s risk of developing a disease, such as cancer Also called unclassified variant, variant of unknown significance, and VUS





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