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  • The Complete (but Practical) Guide to Dosing Vancomycin Based on AUC . . .
    Based on current data, your goal should be to aim for an AUC MIC somewhere between 400 and 600 mg·h L (assuming MIC = 1 mg L) This is a fairly narrow therapeutic window AUC MIC > 400 mg·h L is to maintain efficacy, meaning you want it to work against that infection
  • Therapeutic monitoring of vancomycin for serious methicillin-resistant . . .
    These consensus guidelines recommend an AUC MIC ratio of 400–600 mg*hour L (assuming a broth microdilution MIC of 1 mg L) to achieve clinical efficacy and ensure safety for patients being trea ted for serious methicillin-resistant Staphylococcus aureus infections
  • Evaluating Vancomycin Clinical Outcomes Using Area under the Curve . . .
    AUC based dosing has shown to reduce incidence of acute kidney injury (AKI), utilize lower daily doses in obese patients, and maintain efficacy Several institutions have adjusted their protocols to utilize AUC guided dosing However, there are li-mited studies comparing the clinical outcomes of AUC versus trough moni-toring
  • Optimizing Vancomycin Therapy: A Review of AUC Calculation Techniques
    According to the 2020 consensus guidelines for therapeutic monitoring of vancomycin, it is recommended to target an area under the curve (AUC) of 400-600 mg*h L to optimize vancomycin efficacy and minimize toxicity 1 The guidelines propose 2 methods for calculating vancomycin's AUC: employing a first-order pharmacokinetic (PK) equation or
  • Antimicrobial Fundamental Concepts - University of California, Los Angeles
    Pharmacodynamics describe the relationship of antibiotic concentration to pharmacologic effect or microorganism death The three main pharmacodynamic parameters that are used are the peak to minimal inhibitory concentration ratio (peak MIC), the AUC to MIC ratio (AUC MIC), and the time the drug concentration remains above the MIC (T>MIC)
  • The monitoring of vancomycin: a systematic review and meta-analyses of . . .
    We identified VCM trough concentrations and AUC values that correlated with effectiveness and safety Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed potential for decreasing nephrotoxicity
  • Infection Prevention and Control Resource Center
    Effective infection prevention and control practices, along with antibiotic stewardship, are essential for preventing disease spread, safeguarding vulnerable populations, and maintaining a safe environment
  • CDCs Core Infection Prevention and Control Practices for Safe . . .
    Identify and monitor adherence to infection prevention practices and infection control requirements Provide prompt, regular feedback on adherence and related outcomes to healthcare personnel and facility leadership Train performance monitoring personnel and use standardized tools and definitions


















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