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  • KRAS - Wikipedia
    Currently, a few KRAS-targeting drugs are approved for clinical use and, many clinical trials are underway, exploring the therapeutic potential of a wide variety of KRAS-targeting drugs
  • KRAS 靶点：从基础发现到肿瘤治疗的探索之路 - 知乎
    KRAS 是 RAS 家族中最常见的亚型，其基因突变占 RAS 基因突变总数的 85%。 在多种癌症中，如近 90% 的胰腺癌、30-40% 的结肠癌、17% 的子宫内膜癌以及 15-20% 的肺癌（大多为 NSCLC）等，都存在高比例的 KRAS 基因突变。
  • Small-molecule degraders for oncogenic KRAS - Nature
    KRAS, a frequently mutated oncogene, has been challenging to target therapeutically Although covalent inhibitors like sotorasib against KRAS G12C have been developed, their efficacy is often
  • KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic . . .
    Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of KRAS has been considered as being implausible to
  • KRAS Gene - GeneCards | RASK Protein | RASK Antibody
    GeneCards Summary for KRAS Gene KRAS (KRAS Proto-Oncogene, GTPase) is a Protein Coding gene Diseases associated with KRAS include Oculoectodermal Syndromeand Cardiofaciocutaneous Syndrome 2 Among its related pathways are Downstream signaling of activated FGFR2and Prolactin Signaling
  • 关注 | 中检院发表KRAS突变所致癌症的靶向药物治疗综述
    【来源：中国食品药品监管杂志】 近日，中检院在学术期刊Experimental Hematology Oncology（IF 13 5）发表题为“Systematic and precise interventions for KRAS-mutant
  • What’s new in KRAS mutation research? | UT MD Anderson
    “A KRAS inhibitor was considered the holy grail of oncology, but the tumors are finding ways around it ” Because cancer adapts, KRAS inhibitors alone have not generally been able to eliminate tumors, and often the cancer cells become resistant to the drug
  • Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant . . .
    In this work, we sought to define a comprehensive KRAS-dependent transcriptional signature that detects target inhibition in KRAS-mutant cancer patients treated with KRAS mutation–selective inhibitors
  • KRAS gene: MedlinePlus Genetics
    The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS MAPK pathway The protein relays signals from outside the cell to the cell's nucleus
  • The roles of KRAS in cancer metabolism, tumor . . . - Springer
    In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing epigenetic modification via various molecular activities





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