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  • SHMT mutations and whether to address - Phoenix Rising ME CFS Forums
    SHMT is responsible for creating methylfolate and folinic acid, so it's possible you might be needing a bit of those Hmm, I am homozygous CC for SHMT1 rs9909104 Only 4% of Europeans have that And Watsonbell --- Valentijn, is there any reason to take both folinic acid and methylfolate as supplements?
  • MTHFR, SHMT and folinic acid? - Phoenix Rising ME CFS Forums
    It seemed to me that SHMT + + shouldn't be that big a problem because of this second pathway But, as Valentijn points out, there is research to say that it's a problem if you are C677T compromise There is no research on the combination I was interested in: SHMT and MTHFR A1296C If you come across any studies about it, please pass it on!
  • 23 me question | Phoenix Rising ME CFS Forums
    Some notes I had on VDR, SHMT: Serine hydroxymethyltransferase (SHMT1) is important for linked reactions The first is the conversion of tetrahydrofolate to 5,10-methylenetetrahydrofolate The second is the conversion of L-serine to glycine It also has a role in mediating the synthesis of dTMP and SAM
  • 23andme results | Phoenix Rising ME CFS Forums
    I don't see the result for SHMT, so I can't comment on that You have one First Priority mutation, which is CBS, along with some BHMTs which can add to CBS If you start on methyl supps and have a stress anxiety reaction or a head pressure, CBS could be expressed, causing these problems The Heartfixer page has good info on doing additional testing to see if CBS is expressed, and then a
  • CBS Protocol | Phoenix Rising ME CFS Forums
    AVS - SHMT and CBS are First Priority mutations, so you would treat them first Your CBS is the minor one, and your sulfate strip results are ok, so I think you can skip that one You're not reporting getting a stress anxiety response from methyl supps, so that's an additional clue that it's not a problem
  • It is known that virus infection induces massive production of free . . .
    Superoxide then undergoes spontaneous or enzymatic dismutation via superoxide dismutase (SOD) to generate hydrogen peroxide Although hydrogen peroxide is relatively stable, subsequent interactions with superoxide radicals and or transition metals such as Fe2+ or Cu2+ induce production of the highly toxic hydroxyl radical by Haber-Weiss and Fenton chemistry This radical, the hydroxyl radical
  • Help with interpreting please! | Phoenix Rising ME CFS Forums
    On the methylation SNPs, you have a couple of First Priority mutations which are SHMT and CBS For SHMT take folinic acid For CBS, if it's expressed, you may have trouble tolerating methyl supplements and get a stress anxiety reaction or a head pressure If this is the case, you'll need to do a CBS protocol first so you can tolerate methyl supps You have a mutation on the major CBS gene and
  • MTHFS defect (folinic acid intolerance) - request for genetic data
    A down-reg would cause a build up of folinic acid and thus inhibition of SHMT (and several other enzymes outside the methylation cycle as well) and create an intolerance to supplementation An up-reg can cause an increased turnover rate and depletion of cellular folate
  • Abnormal breathing patterns identified in people with ME CFS
    My guess is that significantly more people who are suffering from various health problems--not just ME--have abnormal breathing patterns Breathing retraining may help some of those people, whether for ME symptoms or non-ME symptoms Likewise, some people suffer from abnormal sleeping patterns, and some of those may benefit from some different techniques The same applies to other aspects of





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