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  • Fosgonimeton - ALZFORUM
    Background NDX-1017 is a brain-penetrant small molecule that activates signaling via the hepatocyte growth factor (HGF) MET receptor system (Moebius and Church, 2023) HGF promotes proliferation and survival of neurons, enhances hippocampal synaptic plasticity, and boosts learning and memory (Akimoto et al , 2004; Kato et al , 2012) NDX-1017 is being developed as a subcutaneous once-daily
  • Long-Term Hydromethylthionine Treatment Is Associated with Delayed . . .
    Bentham P, Staff RT, Schelter BO, Shiells H, Harrington CR, Wischik CM Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier J Alzheimers Dis 2021;83 (3):1017-1023 PubMed Recommends Please login to recommend the paper
  • Mayo normative studies: regression-based normative data for . . . - ALZFORUM
    Karstens AJ, Christianson TJ, Lundt ES, Machulda MM, Mielke MM, Fields JA, Kremers WK, Graff-Radford J, Vemuri P, Jack CR Jr, Knopman DS, Petersen RC, Stricker NH Mayo normative studies: regression-based normative data for ages 30-91 years with a focus on the Boston Naming Test, Trail Making Test and Category Fluency J Int Neuropsychol Soc 2023 Nov 28;:1-13 PubMed
  • Traumatic brain injury and cognitive change over 30 years among . . .
    Schneider AL, Pike JR, Elser H, Coresh J, Mosley TH, Diaz-Arrastia R, Gottesman RF Traumatic brain injury and cognitive change over 30 years among community-dwelling older adults Alzheimers Dement 2024 Jul 5; PubMed Recommends Please login to recommend the paper
  • Demonstrated brain insulin resistance in Alzheimers disease patients . . .
    Type 2 diabetes has been identified as one of the risk factors for AD Two papers analyzing insulin signaling in the brains of Alzheimer’s disease (AD) patients have been published back to back in the Journal for Clinical Investigation
  • www. alzforum. org
    www alzforum org
  • TPM (Thy-1 PS1. M146V) | ALZFORUM
    Brain Res 2004 Aug 13;1017 (1-2):130-6 PubMed Sasmita AO, Ong EC, Nazarenko T, Mao S, Komarek L, Thalmann M, Hantakova V, Spieth L, Berghoff SA, Barr HJ, Hingerl M, Börensen F, Hirrlinger J, Simons M, Stevens B, Depp C, Nave KA Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease
  • Clinical Trials on Alzheimers Disease 2019 | ALZFORUM
    Following up on its October surprise, Biogen showed more data at the Clinical Trials in Alzheimer’s Disease conference, arguing that disparities in drug exposure explained the puzzlingly different outcomes in its one positive and one negative aborted Phase 3 trials Audience members were put off by the messiness of the data set and not fully convinced by the analysis, but the majority said





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